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Description

Mirogabalin is a novel selective oral ligand for the 2 subunit and is known to have a slower dissociation rate from the 2 subunit than pregabalin

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Li JY, Englund E, Holton JL, et al

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Elbaz M, Nasser MW, Ravi J, Wani NA, Ahirwar DK, Zhao H, Oghumu S, Satoskar R, Abhay K, Shilo WEC, Ganju K, Ramesh, (2015) Modulation of the tumor microenvironment and inhibition of EGF/EGFR pathway: novel anti-tumor mechanisms of cannabidiol in breast cancer

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CYP hydroxylases (primarily CYP4A and CYP4F families) produce 20-HETE, a potent vasoconstrictor that regulates renal and cerebral blood flow by inhibiting the large-conductance calcium-activated potassium channel in vascular smooth muscle

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